Haematological, Biochemical and Toxicological Investigations in Spontaneous Cases with Different Frequency of Porcine Nephropathy in Bulgaria
- 12 February 1998
- journal article
- Published by Wiley in Journal of Veterinary Medicine Series A
- Vol. 45 (1-10), 229-236
- https://doi.org/10.1111/j.1439-0442.1998.tb00822.x
Abstract
Haematological, biochemical and toxicological investigations of blood and urine of normally slaughtered pigs exhibiting different frequency (1-2%, 10-20% and 50-60%) of changes characterized as "enlarged mottled kidneys", at the slaughtering meat inspection were carried out to elucidate the nature of nephropathies encountered in Bulgaria. A content of ochratoxin A, higher in the spring than the autumn, was found in the serum and urine samples. The mean contamination levels of ochratoxin A in consumed feeds ranged from 114 +/- 36 ppb for 1994 to 207 +/- 65 ppb for 1993. The renal changes were characterized by impairment of proximal tubular function (indicated by an increased urinary excretion of glucose and protein) as well as by decreased specific gravity and increased pH in the urine mainly in pigs with 50-60% frequency of nephropathy. The concentration of urea, creatinine and glucose in the blood was increased, whereas the serum protein and cholesterol were decreased in pigs with 10-20% and 50-60% frequency of nephropathy. The mean enzyme levels of gamma-glutamyl transpeptidase and leucine aminopeptidase were significantly increased in the urine. The presence of granular casts and necrotic renal tubular cells were established in the sediment.Keywords
This publication has 14 references indexed in Scilit:
- Ochratoxin A in wheat: An intercomparison of proceduresFood Additives & Contaminants, 1993
- Some features of Balkan endemic nephropathyFood and Chemical Toxicology, 1992
- Ochratoxin A in Swine Blood Used for Evaluation of Cereal Handling ProceduresJournal of Veterinary Medicine, Series B, 1990
- Renal enzyme activities in experimental ochratoxin A‐induced porcine nephropathy: Diagnostic potential of phosphoenolpyruvate carboxykinase and gamma‐glutamyl transpeptidase activityJournal of Toxicology and Environmental Health, 1988
- Feeding Experiments with Ochratoxin a Contaminated Barley for Bacon PigsActa Agriculturae Scandinavica, 1983
- Feeding Experiments with Ochratoxin A-contaminated Barley to Bacon PigsActa Agriculturae Scandinavica, 1983
- Inhibition of pancreatic carboxypeptidase A: A possible mechanism of interaction between penicillic acid and ochratoxin AJournal of Environmental Science and Health, Part B, 1982
- Ochratoxin A, an inhibitor of mitochondrial transport systemsBiochemistry, 1974
- Epithelial Cells in Urine SedimentsAmerican Journal of Clinical Pathology, 1971
- Urinalysis and the Urinary SedimentMedical Clinics of North America, 1971