Down-Regulation and Growth Inhibitory Role of C/EBPα in Breast Cancer
Open Access
- 1 May 2005
- journal article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 11 (9), 3184-3190
- https://doi.org/10.1158/1078-0432.ccr-04-2625
Abstract
Purpose: CCAAT/enhancer binding proteins (C/EBP) are a family of transcription factors that regulate proliferation and differentiation in a variety of tissues. The purpose of this study was to explore the possibility that C/EBPα is involved in breast cancer.Keywords
This publication has 32 references indexed in Scilit:
- The CCAAT Enhancer-binding Protein α (C/EBPα) Requires a SWI/SNF Complex for Proliferation ArrestPublished by Elsevier BV ,2004
- Gene expression profiling predicts clinical outcome of breast cancerNature, 2002
- C/EBPα Inhibits Cell Growth via Direct Repression of E2F-DP-Mediated TranscriptionMolecular and Cellular Biology, 2000
- CCAAT/Enhancer-binding Protein δ Regulates Mammary Epithelial Cell G0 Growth Arrest and ApoptosisJournal of Biological Chemistry, 1999
- The C/EBPβ transcription factor regulates epithelial cell proliferation and differentiation in the mammary glandGenes & Development, 1998
- C/EBPβ, but not C/EBPα, is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary glandGenes & Development, 1998
- Expression of CCAAT/Enhancer Binding Proteins (C/EBP) is Associated with Squamous Differentiation in Epidermis and Isolated Primary Keratinocytes and is Altered in Skin NeoplasmsJournal of Investigative Dermatology, 1998
- Terminal Differentiation of Human Breast Cancer through PPARγMolecular Cell, 1998
- Ectopic expression of the CCAAT/enhancer-binding protein alpha promotes the adipogenic program in a variety of mouse fibroblastic cells.Genes & Development, 1994
- Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.Genes & Development, 1991