Cell Wall Chitosan Is Necessary for Virulence in the Opportunistic Pathogen Cryptococcus neoformans
- 1 September 2011
- journal article
- Published by American Society for Microbiology in Eukaryotic Cell
- Vol. 10 (9), 1264-1268
- https://doi.org/10.1128/ec.05138-11
Abstract
Cryptococcus neoformans is an opportunistic fungal pathogen that causes meningoencephalitis. Its cell wall is composed of glucans, proteins, chitin, and chitosan. Multiple genetic approaches have defined a chitosan-deficient syndrome that includes slow growth and decreased cell integrity. Here we demonstrate chitosan is necessary for virulence and persistence in the mammalian host.Keywords
This publication has 30 references indexed in Scilit:
- Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDSAIDS, 2009
- PKC1 Is Essential for Protection against both Oxidative and Nitrosative Stresses, Cell Integrity, and Normal Manifestation of Virulence Factors in the Pathogenic Fungus Cryptococcus neoformansEukaryotic Cell, 2008
- Pulmonary cryptococcosis induces chitinase in the ratRespiratory Research, 2008
- Chitosan, the Deacetylated Form of Chitin, Is Necessary for Cell Wall Integrity in Cryptococcus neoformansEukaryotic Cell, 2007
- Clinical efficacy of new antifungal agentsCurrent Opinion in Microbiology, 2006
- A Chitin Synthase and Its Regulator Protein Are Critical for Chitosan Production and Growth of the Fungal Pathogen Cryptococcus neoformansEukaryotic Cell, 2005
- Function of the thioredoxin proteins in Cryptococcus neoformans during stress or virulence and regulation by putative transcriptional modulatorsMolecular Microbiology, 2005
- Practice Guidelines for the Management of Cryptococcal DiseaseClinical Infectious Diseases, 2000
- Increased Fluconazole Resistance of Cryptococcus neoformans Isolated from a Patient with AIDS and Recurrent MeningitisClinical Infectious Diseases, 1994
- Molecular weight distribution of chitosan isolated from Mucor rouxii under different culture and processing conditionsBiotechnology & Bioengineering, 1992