Aseptic loosening
- 15 January 2004
- journal article
- review article
- Published by Springer Science and Business Media LLC in Gene Therapy
- Vol. 11 (4), 402-407
- https://doi.org/10.1038/sj.gt.3302202
Abstract
Although total joint replacement surgery is one of the most successful clinical procedures performed today, bone loss around knee and hip implants (osteolysis), resulting in aseptic loosening of the prosthesis, remains a major problem for many patients. Over the last decade much has been learned about this process, which is caused by wear debris particles that simulate a local inflammatory response and osteoclastic bone resorption. Aseptic loosening cannot be prevented or treated by existing nonsurgical methods. Gene transfer, however, offers novel possibilities. Here, we review the current state of the field and the experimental gene therapy approaches that have been investigated toward a solution to aseptic loosening of prosthetic implants.This publication has 78 references indexed in Scilit:
- Expression of functional RANK on mature rat and human osteoclastsFEBS Letters, 1999
- RANK Is the Essential Signaling Receptor for Osteoclast Differentiation Factor in OsteoclastogenesisBiochemical and Biophysical Research Communications, 1998
- Nitric oxide release by macrophages in response to particulate wear debrisJournal of Biomedical Materials Research, 1998
- Effects of polyethylene particles on tissue surrounding knee arthroplasties in rabbitsJournal of Biomedical Materials Research, 1998
- In vitro activation of human fibroblasts by retrieved titanium alloy wear debrisJournal of Orthopaedic Research, 1996
- Drug Inhibition of the Macrophage Response to Metal Wear Particles In VitroClinical Orthopaedics and Related Research, 1996
- ANALYSIS OF CELL TYPES AND MEDIATOR PRODUCTION FROM TISSUES AROUND LOOSENING JOINT IMPLANTSRheumatology, 1995
- Polymethylmethacrylate-stimulated macrophages increase rat osteoclast precursor recruitment through their effect on osteoblastsin vitroJournal of Orthopaedic Research, 1995
- The effect of an interleukin‐1 receptor antagonist protein on type ii collagen–induced arthritis and antigen‐induced arthritis in miceArthritis & Rheumatism, 1993
- Interleukin-1 receptor antagonist (IL-1ra) as a probe and as a treatment for IL-1 mediated diseaseInternational Journal of Immunopharmacology, 1992