Solitary Peripheral Ciliated Glandular Papillomas of the Lung
- 1 October 2008
- journal article
- case report
- Published by Ovid Technologies (Wolters Kluwer Health) in The American Journal of Surgical Pathology
- Vol. 32 (10), 1489-1494
- https://doi.org/10.1097/pas.0b013e31817a9061
Abstract
We report 3 cases of solitary papillomas located in peripheral regions of the lung that are extremely rare in the literature. The patients were 75-year-old and 72-year-old men and a 53-year-old woman. One patient complained of recurrent hemoptysis. The other 2 had no symptoms, but abnormal nodular shadows were revealed by chest radiographs during a health check. The maximum diameters of the tumors were 1.0, 1.4, and 1.1 cm, respectively. The 3 tumors gave almost the same histologic findings. Papillomatous fronds lined by a stratified columnar epithelium were seen in the lumens of peripheral bronchi, bronchioles, or alveoli. The stratified columnar epithelium consisted of ciliated, mucous, and basal cells. The neoplastic epithelium extended to the alveolar region and showed a similar appearance to bronchioloalveolar or papillary type adenocarcinomas. For differential diagnosis, it is noteworthy that endobronchiolar papillomatous fronds constantly exist and spreading along alveolar walls is limited in adjacent alveoli in peripheral papillomas. The presence of ciliated cells and basal cells is considered an important finding to suggest benign character of the lesion.Keywords
This publication has 11 references indexed in Scilit:
- Solitary squamous cell papilloma of the lung in a 40‐year‐old woman with recurrent laryngeal papillomatosisPathology International, 2000
- Solitary Pulmonary Papillomas in AdultsThe American Journal of Surgical Pathology, 1998
- Detection of capsid antigen of human papillomavirus (HPV) in benign lesions of female genital tract using anti‐HPV monoclonal antibodyThe Journal of Pathology, 1992
- Columnar Papilloma of the Bronchus: Case Report and Literature ReviewAmerican Review of Respiratory Disease, 1991
- Bronchial Papillomas of Various OriginsSocial psychiatry. Sozialpsychiatrie. Psychiatrie sociale, 1987
- Solitary squamous papilloma of the bronchus.Thorax, 1985
- Is the Solitary Papilloma of the Bronchus Always a Benign Tumor?ORL, 1981
- Solitary papilloma of a bronchusJournal of Clinical Pathology, 1965
- Bronchial PolypsThorax, 1963
- PAPILLOMA OF THE BRONCHUSJournal of Thoracic Surgery, 1954