Semaphorin Signaling in Vascular and Tumor Biology
- 1 January 2007
- book chapter
- review article
- Published by Springer Science and Business Media LLC in Advances in Experimental Medicine and Biology
- Vol. 600, 118-131
- https://doi.org/10.1007/978-0-387-70956-7_10
Abstract
The neuropilins were originally characterized as cell membrane receptors that bind axon guidance factors belonging to the class-3 semaphorin subfamily. To transduce semaphorin signals, they form complexes with members of the plexin receptor family in which neuropilins serve as the ligand binding components and the plexins as the signal transducing components. The neuropilins were subsequently found to double as receptors for specific heparin binding splice forms of vascular endothelial growth factor (VEGF), and to be expressed on endothelial cells. This finding suggested that semaphorins may function as modulators of angiogenesis. It was recently found that several types of semaphorins such as semaphorin-3F function as inhibitors of angiogenesis while others, most notably semaphorin-4D, function as angiogenic factors. Furthermore, semaphorins such as semaphorin-3F and semaphorin-3B have been characterized as tumor suppressors and have been found to exert direct effects upon tumor cells. In this chapter we cover recent developments in this rapidly developing field of researchThis publication has 101 references indexed in Scilit:
- Dual Functional Activity of Semaphorin 3B Is Required for Positioning the Anterior CommissureNeuron, 2005
- The Semaphorin 4D Receptor Plexin-B1 Is a GTPase Activating Protein for R-RasScience, 2004
- Differential MAP kinases activation during semaphorin3A-induced repulsion or apoptosis of neural progenitor cellsMolecular and Cellular Neuroscience, 2004
- Characterization of Insulin Inhibition of Transactivation by a C-terminal Fragment of the Forkhead Transcription Factor Foxo1 in Rat Hepatoma CellsJournal of Biological Chemistry, 2003
- The Semaphorin 4D receptor controls invasive growth by coupling with MetNature, 2002
- Human Semaphorin 6B [(HSA)SEMA6B], A Novel Human Class 6 Semaphorin Gene: Alternative Splicing and All-Trans-Retinoic Acid-Dependent Downregulation in Glioblastoma Cell LinesGenomics, 2001
- Identification of a Novel Transmembrane Semaphorin Expressed on LymphocytesPublished by Elsevier BV ,1996
- Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endotheliumNature, 1995
- Failure of blood-island formation and vasculogenesis in Flk-1-deficient miceNature, 1995
- Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factorBiochemical and Biophysical Research Communications, 1992