THE FORMATION OF A NEW ENZYMATICALLY ACTIVE PROTEIN AS A RESULT OF SUPPRESSION
- 1 August 1959
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 45 (8), 1280-1287
- https://doi.org/10.1073/pnas.45.8.1280
Abstract
Certain tryptophan auxotrophs of Escherichia coli form a defective A protein, one of the components of the tryptophan synthetase enzyme system. Examination of suppressed mutant of one such strain reveals that, in addition to the altered protein characteristic of the unsuppressed mutant, an A protein with normal catalytic activity is present. Hypotheses for the formation of the 2nd A protein are discussed.This publication has 10 references indexed in Scilit:
- A second reaction catalyzed by the tryptophan synthetase of Escherichia coliBiochimica et Biophysica Acta, 1959
- ON A MECHANISM OF SUPPRESSOR GENE REGULATION OF TRYPTOPHAN SYNTHETASE ACTIVITY IN NEUROSPORA CRASSAProceedings of the National Academy of Sciences of the United States of America, 1959
- COMPLEMENTATION AT THE AD-4 LOCUS IN NEUROSPORA CRASSAProceedings of the National Academy of Sciences of the United States of America, 1958
- ON THE SEPARATION OF THE TRYPTOPHAN SYNTHETASE OF ESCHERICHIA COLI INTO TWO PROTEIN COMPONENTSProceedings of the National Academy of Sciences of the United States of America, 1958
- Restoration of Tryptophan Synthetase Activity in Escherichia coli by Suppressor MutationsScience, 1958
- CORRIGENDAGenetics, 1955
- Gene Interactions: the Mode of Action of the Suppressor of Acetate-requiring Mutants of Neurospora crassaJournal of General Microbiology, 1954
- The Effect of a Suppressor on Allelic Inositolless Mutants in Neurospora CrossaProceedings of the National Academy of Sciences of the United States of America, 1953
- Studies on a Suppressor of Non-Allelic Acetate-Requiring Mutants of NeurosporaProceedings of the National Academy of Sciences of the United States of America, 1952