Trends in immunotherapy of fungal infections
- 1 January 1997
- journal article
- review article
- Published by Springer Science and Business Media LLC in European Journal of Clinical Microbiology & Infectious Diseases
- Vol. 16 (1), 51-55
- https://doi.org/10.1007/bf01575121
Abstract
Fungal infections are the primary cause of mortality in patients with severely impaired host defense mechanisms, such as neutropenic patients with acute leukemia or those who have undergone bone marrow transplantation. In view of the unacceptably high mortality due to disseminated candidiasis, it is rational to focus on augmentation of host defense mechanisms in addition to conventional antifungal therapy. In vitro, a variety of immunomodulators, including tumor necrosis factor, interferon-g, and the hematopoietic growth factors, enhance the killing ofCandida albicans, Aspergillus fumigatus, andCryptococcus neoformans. Various studies have demonstrated beneficial effects of immunomodulatory therapy in animal models of disseminated candidiasis. For further preclinical and clinical studies, recombinant interferon-g, interleukin-1, granulocyte colony-stimulating factor, and the other hematopoietic growth factors are currently the most promising immunomodulators.Keywords
This publication has 42 references indexed in Scilit:
- Beneficial Effect of Recombinant Human Granulocyte Colony-Stimulating Factor on Fungicidal Activity of Polymorphonuclear Leukocytes from Patients with AIDSThe Journal of Infectious Diseases, 1995
- In Vivo Activity Of Interferon- In Combination With Amphotericin B In The Treatment Of Experimental CryptococcosisThe Journal of Infectious Diseases, 1994
- Cytokines in the treatment of fungal infectionsBiotherapy, 1994
- Macrophage Colony-Stimulating Factor Induction of Enhanced Macrophage Anticryptococcal Activity: Synergy with Fluconazole for KillingThe Journal of Infectious Diseases, 1994
- Antifungal Activity of Recombinant Human Macrophage Colony-Stimulating Factor in Models of Acute and Chronic Candidiasis in the RatThe Journal of Infectious Diseases, 1994
- Recombinant Interferon- Enhances Resistance to Acute Disseminated Candida albicans Infection in MiceThe Journal of Infectious Diseases, 1993
- Granulocyte colony-stimulating factor potentiates anti-Candida albicansgrowth inhibitory activity of polymorphonuclear cellsFEMS Immunology & Medical Microbiology, 1993
- Neutralizing antibody to interleukin 4 induces systemic protection and T helper type 1-associated immunity in murine candidiasis.The Journal of Experimental Medicine, 1992
- In Vivo Interferon- Therapy Augments the In Vitro Ability of Chronic Granulomatous Disease Neutrophils to Damage Aspergillus HyphaeThe Journal of Infectious Diseases, 1991
- Protection of neutropenic mice from lethal Candida albicans infection by recombinant interleukin 1European Journal of Immunology, 1988