Genome‐wide linkage scan for prostate cancer susceptibility from the university of michigan prostate cancer genetics project: Suggestive evidence for linkage at 16q23
- 26 November 2008
- journal article
- research article
- Published by Wiley in The Prostate
- Vol. 69 (4), 385-391
- https://doi.org/10.1002/pros.20891
Abstract
BACKGROUND Prostate cancer linkage studies have been used to localize rare and presumably highly penetrant cancer susceptibility genes. Underlying genetic heterogeneity, as well as the high sporadic background of the disease, has resulted in many signals that are often not reproducible between research studies. METHODS We conducted a SNP‐based genome wide linkage scan on 131 Caucasian prostate cancer families participating in the University of Michigan Prostate Cancer Genetics Project (PCGP). RESULTS The strongest evidence for linkage was detected at 16q23 (LOD = 2.70 at rs1079635). Prostate cancer linkage to the same region of 16q23 has been observed by others and the region contains several strong candidate genes including the known prostate cancer tumor suppressor genes ATBF1 and WWOX . This linkage signal was not detected in our prior linkage study on 175 PCGP families, illustrating the genetic heterogeneity underlying prostate cancer susceptibility. CONCLUSIONS Further linkage studies in combination with tumor analyses from linked families are in progress to identify the putative hereditary prostate cancer gene at 16q23. Prostate 69:385–391, 2009.Keywords
Funding Information
- NIH (R01 CA79596, K07 CA127214)
This publication has 125 references indexed in Scilit:
- Routes to the past: Neural substrates of direct and generative autobiographical memory retrievalNeuroImage, 2012
- The familiarity/recollection distinction does not illuminate medial temporal lobe function: response to Montaldi and MayesTrends in Cognitive Sciences, 2011
- Three dimensional echo-planar imaging at 7 TeslaNeuroImage, 2010
- Shared and selective neural correlates of inhibition, facilitation, and shifting processes during executive controlNeuroImage, 2010
- Overlapping brain activity between episodic memory encoding and retrieval: Roles of the task-positive and task-negative networksNeuroImage, 2009
- Common and specific brain regions in high- versus low-confidence recognition memoryBrain Research, 2009
- The retrieval of learned sequences engages the hippocampus: Evidence from fMRIHippocampus, 2009
- The effect of scene context on episodic object recognition: Parahippocampal cortex mediates memory encoding and retrieval successHippocampus, 2007
- The functional neuroanatomy of autobiographical memory: A meta-analysisNeuropsychologia, 2006
- Genetic dissection of complex traits: guidelines for interpreting and reporting linkage resultsNature Genetics, 1995