Abnormal Intestinal Permeability Pattern in Colonic Crohn's Disease: Absorption of Low Molecular Weight Polyethylene Glycols after Oral or Colonic Load
- 1 January 1989
- journal article
- research article
- Published by Informa UK Limited in Scandinavian Journal of Gastroenterology
- Vol. 24 (5), 571-576
- https://doi.org/10.3109/00365528909093091
Abstract
Intestinal permeability to different-sized polyethylene glycols in Crohn's disease of the colon was compared with that in ileal Crohn's disease and in controls without inflammatory bowel affection. The permeability was assessed both after ingestion of the marker (oral load) and after deposition in the colon during colonoscopy (colonic load). After oral load the absorption was least in the patients with colonic Crohn's disease, intermediate in ileal disease, and greatest in the controls. After colonic load, however, the values were highest in colonic Crohn's disease. The study indicated that in Crohn's disease of the colon there is abnormal permeability in apparently uninvolved proximal small intestine as well as in the colon. Since oral load tests preferentially reflect the absorptive properties of the proximal small bowel, regional tests of absorption are important when the aim is to assess the permeability of the distal small intestine or the colon.Keywords
This publication has 13 references indexed in Scilit:
- Intestinal permeability to polyethyleneglycol 600 in Crohn's disease. Peroperative determination in a defined segment of the small intestine.Gut, 1988
- Lactulose 51Cr-labelled ethylenediaminetetra-acetate, l-rhamnose and polyethyleneglycol 500 as probe markers for assessment in vivo of human intestinal permeabilityClinical Science, 1986
- Alterations of the Intestinal Mucosal Block in Ulcerative Colitis and Crohn's Disease - Immunological and Ultrastructural Findings, and Considerations of the Pathogenesis*Klinische Padiatrie, 1985
- Passage of Molecules through the Wall of the Gastrointestinal TractScandinavian Journal of Gastroenterology, 1983
- Total parenteral nutrition as the sole therapy in Crohn's disease—a prospective studyBritish Journal of Surgery, 1983
- The “Early” Ulcerative Lesion of Crohnʼs DiseaseJournal of Clinical Gastroenterology, 1980
- Comparison of the Results of Resection, Bypass, and Bypass with Exclusion for Ileocecal Crohnʼs DiseaseAnnals of Surgery, 1978
- THE PATHOGENESIS OF CROHN'S DISEASEThe Lancet, 1977
- Enzymatic and morphometric evidence for Crohn's disease as a diffuse lesion of the gastrointestinal tract.Gut, 1977
- Crohn's Disease (Regional Enteritis) of the Large Intestine and its Distinction from Ulcerative ColitisGut, 1960