Role of photodynamic therapy in the treatment of esophageal cancer
- 22 January 2019
- journal article
- review article
- Published by Wiley in Digestive Endoscopy
- Vol. 31 (5), 508-516
- https://doi.org/10.1111/den.13353
Abstract
Photodynamic therapy (PDT), a treatment of choice for cancer, induce photochemical reaction, thereby eradicating tumor cells. This is achieved through the administration of a photosensitizer drug, which is activated with a laser after localization to the tumor mass, and is an approved curative endoscopic ablative treatment for superficial esophageal squamous cell carcinoma (ESCC) in Japan. PDT has been approved for dysplastic Barrett 's esophagus and as a palliative treatment for patients with symptomatic obstructive esophageal cancer in US. However, its adverse events and complicated procedure and the development of alternative endoscopic procedures such as endoscopic submucosal dissection, radio frequency ablation and cryotherapy, have largely limited the practice of PDT in esophageal cancer worldwide. Recently, owing to the invention of second‐generation PDT using talaporfin sodium and diode laser, PDT can be performed with less phototoxicity and therefore has regained popularity in the treatment of ESCC. As a salvage treatment for patients with local failure after chemoradiotherapy (CRT), PDT has shown promising complete response with less phototoxicity and shorter sun shade period. And, the efficacy and safety of PDT in patients with local failure of ESCC after CRT were shown in several clinical trials. The direction of the study‐interest of the next generation PDT is the safety and potential expansion of the indications for its application in the future. This review covers the PDT for the treatment of ESCC and dysplastic Barrett 's esophagus, with special focus on the role of PDT in practice for esophageal cancer.Keywords
This publication has 62 references indexed in Scilit:
- Trends in esophageal adenocarcinoma incidence and mortalityCancer, 2012
- Phase I study of photodynamic therapy using talaporfin sodium and diode laser for local failure after chemoradiotherapy for esophageal cancerRadiation Oncology, 2012
- Tissue Damage in the Canine Normal Esophagus by Photoactivation with Talaporfin Sodium (Laserphyrin): A Preclinical StudyPLOS ONE, 2012
- Individualized, multimodal palliative treatment of inoperable esophageal cancer: Clinical impact of photodynamic therapy resulting in prolonged survivalLasers in Surgery and Medicine, 2012
- Photodynamic therapy of cancer: An updateCA: A Cancer Journal for Clinicians, 2011
- Photodynamic therapy for large superficial squamous cell carcinoma of the esophagusGastrointestinal Endoscopy, 2011
- Epidemiology of Esophageal CancerGastroenterology Clinics of North America, 2009
- Long-Term Survival Following Endoscopic and Surgical Treatment of High-Grade Dysplasia in Barrett’s EsophagusGastroenterology, 2007
- Photodynamic therapy and anti-tumour immunityNature Reviews Cancer, 2006
- Photodynamic therapy with porfimer sodium for ablation of high-grade dysplasia in Barrett's esophagus: international, partially blinded, randomized phase III trialGastrointestinal Endoscopy, 2005