Lesions mimicking lacrimal gland pleomorphic adenoma
- 20 October 2010
- journal article
- research article
- Published by BMJ in British Journal of Ophthalmology
- Vol. 94 (11), 1509-1512
- https://doi.org/10.1136/bjo.2008.156307
Abstract
Aim To report a series of patients with lacrimal gland lesions simulating the clinicoradiological features of lacrimal gland pleomorphic adenoma (LGPA). Methods Multicentre retrospective, interventional case series. Clinical records of all patients with lesions mimicking LGPA seen in five orbital units were reviewed. Results The study included 14 patients (seven men and seven women) with a mean age of 50.9 years. The diagnosis of LGPA was made in all cases by experienced orbital surgeons, based on clinicoradiological features, and lacrimal gland excision was performed. Postoperative histology revealed lymphoma (four patients), chronic dacryoadenitis (three patients), adenoid cystic carcinoma (two patients), Sjogren's syndrome (two patients), cavernous haemangioma (one patient), benign lymphoid hyperplasia (one patient) and granulomatous dacryoadenitis (one patient). Comparison with the total number of histologically confirmed LGPA cases seen during the study period revealed that 22.6% of cases of suspected LGPA were misdiagnosed based on clinicoradiological criteria. Conclusions Many different lesions may mimic the clinicoradiological features of LGPA. The accepted clinicoradiological criteria used for the diagnosis of LGPA have a high false-positive rate, even in experienced hands. Based on this study, the authors believe that fine-needle aspiration biopsy or intraoperative biopsy and frozen section diagnosis may help reduce unnecessary lacrimal gland excision.Keywords
This publication has 12 references indexed in Scilit:
- Pleomorphic adenoma of the lacrimal gland: is there a role for biopsy?Eye, 2008
- Lacrimal Gland Pleomorphic Adenomas With Low-density Zones Resembling Cystic Change on Computed TomographyOphthalmic Plastic & Reconstructive Surgery, 2007
- Unusual Progression of Pleomorphic Adenoma of the Lacrimal Gland-Case Report-Neurologia medico-chirurgica, 2005
- Pleomorphic adenomas of the lacrimal gland: a clinicopathological analysisClinical & Experimental Ophthalmology, 2004
- Fine-Needle Aspiration Biopsy of Salivary Gland Lesions in a Selected Patient PopulationJAMA Otolaryngology–Head & Neck Surgery, 2004
- Pleomorphic Adenoma of the Lacrimal Gland With Extensive CalcificationAmerican Journal of Ophthalmology, 2004
- Role of fine needle aspiration cytology in diagnosis of pleomorphic adenomasCytopathology, 2002
- Recurrent pleomorphic adenomas of the parotid glandHead & Neck, 1990
- In situ malignant mixed tumour of the lacrimal gland Case report and reviewOrbit, 1987
- Lacrimal Gland Tumors: A Clinicopathological Analysis of 160 CasesInternational Ophthalmology Clinics, 1982