Importance of antibodies to the fusion glycoprotein of paramyxoviruses in the prevention of spread of infection.
Open Access
- 1 February 1980
- journal article
- review article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 151 (2), 275-288
- https://doi.org/10.1084/jem.151.2.275
Abstract
The effects of monospecific antibodies to the viral glycoprotein with hemagglutinating and neuraminidase activity (HN) and the viral glycoprotein with membrane-fusing activity (F) of the paramyxovirus simian virus 5 (SV5) on the spread of infection in two cell types have been investigated. In CV-1 cells, infection can spread by either released progeny virus adsorbing to and infecting other cells, or by fusion of an infected cell with an adjacent cell as a result of the cell-fusing activity of the F glycoprotein. In these cells, antibodies specific for the HN glycoprotein prevented the dissemination of infection by released infectious virus, but spread by cell fusion was not inhibited. Antibodies to the F glycoprotein completely prevented the spread of infection in these cells. In Madin-Darby bovine kidney cells, which are relatively resistant to SV5-induced fusion, antibodies to either the HN or F glycoproteins were capable of preventing the dissemination of infection. These results indicate that effective immunological prevention of the spread of paramyxovirus infection requires the presence of antibodies that inactivate the F glycoprotein. This requirement for anti-F antibodies has obvious implications for the design of effective paramyxovirus vaccines and provides an explanation for previous failures of formalin-inactivated paramyxovirus vaccines as well as additional insight into the possible immunopathological mechanisms involved in the atypical and severe infections that have occurred in individuals who received inactivated paramyxovirus vaccines and were subsequently infected by the virus.This publication has 43 references indexed in Scilit:
- Giant-cell pneumonia caused by parainfluenza virusThe Journal of Pediatrics, 1979
- Parainfluenza pneumonia in severe combined immunodeficiency diseaseThe Journal of Pediatrics, 1979
- Differences in Antibodies to the Surface Components of Mumps Virus after Immunization with Formalin-Inactivated and Live Virus VaccinesThe Journal of Infectious Diseases, 1978
- Immunological injury in "shipping fever" pneumonia of cattleVeterinary Record, 1977
- Differences in the Appearance of Antibodies to Structural Components of Measles Virus after Immunization with Inactivated and Live VirusThe Journal of Infectious Diseases, 1975
- EXPERIMENTAL IMMUNE COMPLEX DISEASE OF THE LUNGThe Journal of Experimental Medicine, 1974
- Antibody-Mediated Fusion of FL Amnion Cells Infected with Parainfluenza Virus Type 2Immunological Communications, 1972
- Parainfluenza Virus Surface Projections: Glycoproteins with Haemagglutinin and Neuraminidase ActivitiesJournal of General Virology, 1971
- Control of Acute Mycoplasmal and Viral Respiratory Tract DiseaseScience, 1970
- Arthus reaction and pneumonia.BMJ, 1970