Spleen R2 and R2* in iron‐overloaded patients with sickle cell disease and thalassemia major
Open Access
- 22 January 2009
- journal article
- research article
- Published by Wiley in Journal of Magnetic Resonance Imaging
- Vol. 29 (2), 357-364
- https://doi.org/10.1002/jmri.21666
Abstract
Purpose To evaluate the magnetic properties of the spleen in chronically transfused, iron‐overloaded patients with sickle cell disease (SCD) and thalassemia major (TM) and to compare splenic iron burdens to those in the liver, heart, pancreas, and kidneys. Materials and Methods A retrospective analysis of 63 TM and 46 SCD patients was performed. Spleen R2 and R2* values were calculated from spin‐echo and gradient‐echo images collected between April 2004 and September 2007. Results The spleen showed a different R2–R2* relationship than that previously established for the liver. At high iron concentrations (R2* > 300 Hz), spleen R2 was lower than predicted for liver. The proportion of splenic to hepatic iron content was greater in SCD patients compared with TM patients (23.8% vs. 13.8%). A weak association was found between splenic and liver iron—this association was stronger in SCD patients. Little correlation was found between splenic iron and extrahepatic R2* values. Conclusion For spleen and liver tissue with the same R2* value, splenic R2 was significantly lower than hepatic R2, particularly for R2* > ≈300 Hz. Splenic iron levels have little predictive value for R2* values of heart, pancreas, and kidney. J. Magn. Reson. Imaging 2009;29:357–364.Keywords
This publication has 42 references indexed in Scilit:
- Magnetic resonance detection of kidney iron deposition in sickle cell disease: A marker of chronic hemolysisJournal of Magnetic Resonance Imaging, 2008
- Influence of iron chelation on R1 and R2 calibration curves in gerbil liver and heartMagnetic Resonance in Medicine, 2008
- Oxidative stress and inflammation in iron‐overloaded patients with β‐thalassaemia or sickle cell diseaseBritish Journal of Haematology, 2006
- Splenectomy: a strong risk factor for pulmonary hypertension in patients with thalassaemiaHeart, 2006
- Improved R2* measurements in myocardial iron overloadJournal of Magnetic Resonance Imaging, 2005
- Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonanceBlood, 2005
- The form of iron oxide deposits in thalassemic tissues varies between different groups of patients: a comparison between Thai β-thalassemia/hemoglobin E patients and Australian β-thalassemia patientsBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1998
- MR Findings of Secondary HemochromatosisJournal of Computer Assisted Tomography, 1994
- Volume of the spleen in children as measured on CT scans: normal standards as a function of body weight.American Journal of Roentgenology, 1993
- Effect of bacterial lipopolysaccharide on the content of lipid peroxidation products in lungs and other organs of miceAntonie van Leeuwenhoek, 1993