Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states
Open Access
- 18 November 2009
- journal article
- Published by Springer Science and Business Media LLC in BMC Cancer
- Vol. 9 (1), 401
- https://doi.org/10.1186/1471-2407-9-401
Abstract
Colon cancer arises from the accumulation of multiple genetic and epigenetic alterations to normal colonic tissue. microRNAs (miRNAs) are small, non-coding regulatory RNAs that post-transcriptionally regulate gene expression. Differential miRNA expression in cancer versus normal tissue is a common event and may be pivotal for tumor onset and progression.Keywords
This publication has 46 references indexed in Scilit:
- The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shoresNature Genetics, 2009
- Genomic and Epigenetic Instability in Colorectal Cancer PathogenesisGastroenterology, 2008
- Analyzing real-time PCR data by the comparative CT methodNature Protocols, 2008
- Systemic Treatment of Colorectal CancerGastroenterology, 2008
- MicroRNA Expression Profiles Associated With Prognosis and Therapeutic Outcome in Colon AdenocarcinomaJAMA, 2008
- Epigenetic inactivation of microRNA gene hsa‐mir‐9‐1 in human breast cancerThe Journal of Pathology, 2007
- Altered Expression of miR-21, miR-31, miR-143 and miR-145 Is Related to Clinicopathologic Features of Colorectal CancerOncology, 2007
- CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancerNature Genetics, 2006
- Oncomirs — microRNAs with a role in cancerNature Reviews Cancer, 2006
- MicroRNA expression profiles classify human cancersNature, 2005