Biomarkers of oxidative stress in fetal and neonatal diseases
- 22 August 2012
- journal article
- review article
- Published by Taylor & Francis Ltd in The Journal of Maternal-Fetal & Neonatal Medicine
- Vol. 25 (12), 2575-2578
- https://doi.org/10.3109/14767058.2012.718004
Abstract
Oxidative stress (OS) is strongly involved in the pathogenesis of many fetal and newborn diseases. A low efficient antioxidant systems in preterm babies are not able to counteract the harmful effects of free radicals (FRs), leading to “FRs-related disease” of newborns promoting cellular, tissue and organ damages. The dangerous effects of FRs are linked to their property of being very unstable molecules and their ability to react with lipids, proteins, polysaccharides, nucleic acids, causing functional alterations within the cell, until cell death. OS is difficult to be measured in vivo, because FRs have a very short half-life. Actually, measurements of lipid peroxidation reach high specificity and sensitivity with the discovery of stable compounds, isoprostanes. Recent studies evaluating the damaging effects of FRs in the perinatal period, have observed a direct relation between the degree of OS and the severity of oxidative damage in the course of pregnancy and in perinatal period, with an interesting predictive role of OS biomarkers for diseases resulting from oxidative injury. The validation of a biomarker profile for early identification of newborns at high risk of OS, will pave the way to new clinical preventative or therapeutic approaches to reduce the prevalence of neonatal disability.Keywords
This publication has 30 references indexed in Scilit:
- May oxidative stress biomarkers in cord blood predict the occurrence of necrotizing enterocolitis in preterm infants?The Journal of Maternal-Fetal & Neonatal Medicine, 2012
- Development of a fast and simple LC-MS/MS method for measuring the F2-isoprostanes in newbornsThe Journal of Maternal-Fetal & Neonatal Medicine, 2012
- Oxygen toxicity: chemistry and biology of reactive oxygen speciesSeminars in Fetal and Neonatal Medicine, 2010
- Early identification of the risk for free radical-related diseases in preterm newbornsEarly Human Development, 2010
- The wanderings of a free radicalFree Radical Biology & Medicine, 2009
- Association between oxidative stress in pregnancy and preterm premature rupture of membranesClinical Biochemistry, 2007
- Isoprostanes in amniotic fluid: a predictive marker for fetal growth restriction in pregnancyFree Radical Biology & Medicine, 2005
- Glutathione Recycling and Antioxidant Enzyme Activities in Erythrocytes of Term and Preterm Newborns at BirthNeonatology, 2004
- Iron release in erythrocytes and plasma non protein-bound iron in hypoxic and non hypoxic newborns.Free Radical Research, 2003
- Biomarkers in molecular epidemiology studies for health risk predictionMutation research. Reviews in mutation research, 2002