Mouse models of global airway allergy: what have we learned and what should we do next?
- 1 September 2004
- Vol. 59 (9), 914-919
- https://doi.org/10.1111/j.1398-9995.2004.00549.x
Abstract
Recent epidemiological and clinical data indicate that allergic rhinitis and asthma coexist and should be considered as one airway allergy syndrome. In spite of the importance of this new concept of global airway allergy, it has not fundamentally changed our daily diagnostic and therapeutic strategies so far because of the lack of essential clues to understand the correlation between allergic inflammation in upper and lower airways. Because of the resemblance of experimentally induced allergic airway inflammation in mice to inflamed airways of allergic patients, mouse models can enhance our insight into mechanisms underlying the global airway allergy syndrome. We here review data generated in mice that are relevant for understanding the development of airway allergy and provide new options for research on the so-called 'united airway diseaseKeywords
This publication has 21 references indexed in Scilit:
- Allergic rhinitis and asthma: the link further unraveledCurrent Opinion in Pulmonary Medicine, 2003
- Pathogenesis of Murine Experimental Allergic Rhinitis: A Study of Local and Systemic Consequences of IL-5 DeficiencyThe Journal of Immunology, 2002
- Eosinophilopoiesis in A Murine Model of Allergic Airway Eosinophilia: Involvement of Bone Marrow IL-5 and IL-5 Receptor αThe Journal of Immunology, 2000
- Scintigraphic evaluation in rabbits of nasal drug delivery systems based on carbopol 971p® and carboxymethylcelluloseJournal of Controlled Release, 2000
- Segmental Bronchial Provocation Induces Nasal Inflammation in Allergic Rhinitis PatientsAmerican Journal of Respiratory and Critical Care Medicine, 2000
- Mucous-Cell Metaplasia and Inflammatory-Cell Recruitment Are Dissociated in Allergic Mice after Antibody- and Drug-Dependent Cell Depletion in a Murine Model of AsthmaAmerican Journal of Respiratory Cell and Molecular Biology, 1999
- Comparison between Nasal and Bronchial Inflammation in Asthmatic and Control SubjectsAmerican Journal of Respiratory and Critical Care Medicine, 1999
- Circulating, but not local lung, IL-5 is required for the development of antigen-induced airways eosinophilia.JCI Insight, 1998
- Rapid Increase in Bone-marrow Eosinophil Production and Responses to Eosinopoietic Interleukins Triggered by Intranasal Allergen ChallengeAmerican Journal of Respiratory Cell and Molecular Biology, 1997
- Lung inflammation and epithelial changes in a murine model of atopic asthma.American Journal of Respiratory Cell and Molecular Biology, 1996