PKB/AKT: functional insights from genetic models
Top Cited Papers
- 1 October 2001
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Molecular Cell Biology
- Vol. 2 (10), 760-768
- https://doi.org/10.1038/35096067
Abstract
Since its discovery 10 years ago, the potential functions of protein kinase B (PKB)/AKT have been catalogued with increasing efficiency. The physiological relevance of some of the proposed mechanisms by which PKB/AKT mediates many of its effects has been questioned, and recent work using new reagents and approaches has revealed some cracks in our understanding of this important molecule, and also hinted that these effects may involve other players.Keywords
This publication has 91 references indexed in Scilit:
- Two Splice Variants of Protein Kinase Bγ Have Different Regulatory Capacity Depending on the Presence or Absence of the Regulatory Phosphorylation Site Serine 472 in the Carboxyl-terminal Hydrophobic DomainPublished by Elsevier BV ,2001
- Mutational Analysis of thePTENGene in Endometrial Carcinoma and HyperplasiaAmerican Journal of Clinical Pathology, 2001
- Lipid phosphatases in the immune systemSeminars in Immunology, 2000
- The conserved PI3′K/PTEN/Akt signaling pathway regulates both cell size and survival in DrosophilaOncogene, 2000
- Mammary gland neoplasia: insights from transgenic mouse modelsBioEssays, 2000
- Protein Kinase B Regulates T Lymphocyte Survival, Nuclear Factor κb Activation, and Bcl-XL Levels in VivoThe Journal of Experimental Medicine, 2000
- The Akt kinase signals directly to endothelial nitric oxide synthaseCurrent Biology, 1999
- Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTENCell, 1998
- High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in miceCurrent Biology, 1998
- Phosphatidylinositol-3-OH kinase direct target of RasNature, 1994