Preclinical and clinical studies of anticancer agent‐incorporating polymer micelles
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Open Access
- 30 March 2009
- journal article
- review article
- Published by Wiley in Cancer Science
- Vol. 100 (4), 572-579
- https://doi.org/10.1111/j.1349-7006.2009.01103.x
Abstract
The size of anticancer agent‐incorporating micelles can be controlled within the diameter range of 20–100 nm to ensure that they do not penetrate normal vessel walls. With this development, it is expected that the incidence of drug‐induced side‐effects may be decreased owing to the reduced drug distribution in normal tissue. Micelle systems can also evade non‐specific capture by the reticuloendothelial system because the outer shell of a micelle is covered with polyethylene glycol. Consequently, a polymer micelle carrier can be delivered selectively to a tumor by utilizing the enhanced permeability and retention effect. Moreover, a water‐insoluble drug can be incorporated into polymer micelles. Presently, several anticancer agent‐incorporating micelle carrier systems are under preclinical and clinical evaluation. Furthermore, nucleic acid‐incorporating micelle carrier systems are also being developed. (Cancer Sci 2009; 100: 572–579)Keywords
This publication has 39 references indexed in Scilit:
- Enhanced distribution of NK012, a polymeric micelle‐encapsulated SN‐38, and sustained release of SN‐38 within tumors can beat a hypovascular tumorCancer Science, 2008
- Synergistic antitumor activity of the novel SN‐38‐incorporating polymeric micelles, NK012, combined with 5‐fluorouracil in a mouse model of colorectal cancer, as compared with that of irinotecan plus 5‐fluorouracilInternational Journal of Cancer, 2008
- A phase I and pharmacokinetic study of NK105, a paclitaxel-incorporating micellar nanoparticle formulationBritish Journal of Cancer, 2007
- Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-β signalingProceedings of the National Academy of Sciences of the United States of America, 2007
- Preparation and biological properties of dichloro(1,2-diaminocyclohexane)platinum(II) (DACHPt)-loaded polymeric micellesJournal of Controlled Release, 2005
- XELOX (Capecitabine Plus Oxaliplatin): Active First-Line Therapy for Patients With Metastatic Colorectal CancerJournal of Clinical Oncology, 2004
- Polyion Complex Micelles Encapsulating Light-Harvesting Ionic Dendrimer Zinc PorphyrinsLangmuir, 2000
- Block copolymer micelles as vehicles for drug deliveryJournal of Controlled Release, 1993
- Polymer micelles as novel drug carrier: Adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymerJournal of Controlled Release, 1990
- Anti-tumour platinum complexes : relationships between chemical properties and activityBiochimie, 1978