Quorum Quenching Enzymes and Their Application in Degrading Signal Molecules to Block Quorum Sensing-Dependent Infection
Open Access
- 25 August 2013
- journal article
- review article
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 14 (9), 17477-17500
- https://doi.org/10.3390/ijms140917477
Abstract
With the emergence of antibiotic-resistant strains of bacteria, the available options for treating bacterial infections have become very limited, and the search for a novel general antibacterial therapy has received much greater attention. Quorum quenching can be used to control disease in a quorum sensing system by triggering the pathogenic phenotype. The interference with the quorum sensing system by the quorum quenching enzyme is a potential strategy for replacing traditional antibiotics because the quorum quenching strategy does not aim to kill the pathogen or limit cell growth but to shut down the expression of the pathogenic gene. Quorum quenching enzymes have been identified in quorum sensing and non-quorum sensing microbes, including lactonase, acylase, oxidoreductase and paraoxonase. Lactonase is widely conserved in a range of bacterial species and has variable substrate spectra. The existence of quorum quenching enzymes in the quorum sensing microbes can attenuate their quorum sensing, leading to blocking unnecessary gene expression and pathogenic phenotypes. In this review, we discuss the physiological function of quorum quenching enzymes in bacterial infection and elucidate the enzymatic protection in quorum sensing systems for host diseases and their application in resistance against microbial diseases.This publication has 103 references indexed in Scilit:
- Quorum sensingProceedings of the National Academy of Sciences of the United States of America, 2013
- Involvement of Multiple Loci in Quorum Quenching of Autoinducer I Molecules in the Nitrogen-Fixing Symbiont Rhizobium (Sinorhizobium) sp. Strain NGR234Applied and Environmental Microbiology, 2011
- Directed Evolution of a Thermostable Quorum-quenching Lactonase from the Amidohydrolase SuperfamilyPublished by Elsevier BV ,2010
- AidH, an Alpha/Beta-Hydrolase Fold Family Member from an Ochrobactrum sp. Strain, Is a Novel N -Acylhomoserine LactonaseApplied and Environmental Microbiology, 2010
- Quorum-Quenching Acylase Reduces the Virulence of Pseudomonas aeruginosa in a Caenorhabditis elegans Infection ModelAntimicrobial Agents and Chemotherapy, 2009
- Metagenome-Derived Clones Encoding Two Novel Lactonase Family Proteins Involved in Biofilm Inhibition in Pseudomonas aeruginosaApplied and Environmental Microbiology, 2009
- Two DissimilarN-Acyl-Homoserine Lactone Acylases ofPseudomonas syringaeInfluence Colony and Biofilm MorphologyApplied and Environmental Microbiology, 2009
- Mechanism of the Quorum-Quenching Lactonase (AiiA) from Bacillus thuringiensis. 2. Substrate Modeling and Active Site MutationsBiochemistry, 2008
- Effects of AiiA-Mediated Quorum Quenching in Sinorhizobium meliloti on Quorum-Sensing Signals, Proteome Patterns, and Symbiotic InteractionsMolecular Plant-Microbe Interactions®, 2007
- Quorum-quenching microbial infections: mechanisms and implicationsPhilosophical Transactions Of The Royal Society B-Biological Sciences, 2007