Clinical and laboratory features of South American rattlesnake (Crotalus durissus terrificus) envenomation in children
- 1 November 1988
- journal article
- Published by Oxford University Press (OUP) in Transactions of the Royal Society of Tropical Medicine and Hygiene
- Vol. 82 (6), 924-929
- https://doi.org/10.1016/0035-9203(88)90044-2
Abstract
The venom of the South American rattlesnake Crotalus durissus terrificus was first reported to have mainly haemolytic and neurotoxic physiopathological activities. Later studies demonstrated the systemic myotoxic action of the venom, characterized by the release of myoglobin from damaged skeletal muscle into serum and urine, and a recent report ruled out the presence of intravascular haemolysis in 3 patients, one child and 2 adults. The present paper describes the clinical-laboratory evolution of 10 children bitten by C. durissus terrificus; 2 developed acute renal failure and one died. The myotoxic activity of the venom was evaluated by measuring serum lactic dehydrogenase, creatine kinase and aspartate aminotransferase, by detection of myoglobin in serum and urine, and by muscle biopsy. Haemolytic activity was evaluated by serial measurements of serum haemoglobin and haptoglobin and by detection of urine haemoglobin. We conclude that the signs and symptoms exhibited by patients bitten by C. durissus terrificus are due only to the myotoxic and neurotoxic action of the venom. The only patients with major morbidity were those who initially received subcutaneous antivenin and did not receive definitive antivenin therapy until later.Keywords
This publication has 16 references indexed in Scilit:
- Severe myonecrosis in a fatal case of envenomation by the canebrake rattlesnake (Crotalus horridus atricaudatus)Toxicon, 1987
- Evidence that Crotalus durissus terrificus (South American rattlesnake) envenomation in humans causes myolysis rather than hemolysisToxicon, 1987
- Rabdomióilise secundária a acidente ofídico crotálico (Crotalus durissus terrificus)Revista do Instituto de Medicina Tropical de São Paulo, 1986
- Myonecrosis, myoglobinuria and acute renal failure induced by south american rattlesnake (Crotalus durissus terrificus) envenomation in brazilToxicon, 1985
- Rhabdomyolysis And Myoglobinuria in ChildhoodPediatric Clinics of North America, 1976
- CLINICAL AND PATHOLOGICAL ASPECTS OF A FATAL CASE OF MULGA (PSEVDECHIS AUSTRALIS) SNAKEBITEThe Medical Journal of Australia, 1969
- MYOGLOBINURIA FOLLOWING SNAKEBITEThe Medical Journal of Australia, 1968
- Method using ortho-tolidine for the quantitative determination of haemoglobin in serum and urineJournal of Clinical Pathology, 1965
- Pathology of Sea-snake PoisoningBMJ, 1961
- Myoglobinuria and Sea-snake-bite PoisoningBMJ, 1961