HSPIR: a manually annotated heat shock protein information resource
Open Access
- 24 August 2012
- journal article
- research article
- Published by Oxford University Press (OUP) in Bioinformatics
- Vol. 28 (21), 2853-2855
- https://doi.org/10.1093/bioinformatics/bts520
Abstract
Summary: Heat shock protein information resource (HSPIR) is a concerted database of six major heat shock proteins (HSPs), namely, Hsp70, Hsp40, Hsp60, Hsp90, Hsp100 and small HSP. The HSPs are essential for the survival of all living organisms, as they protect the conformations of proteins on exposure to various stress conditions. They are a highly conserved group of proteins involved in diverse physiological functions, including de novo folding, disaggregation and protein trafficking. Moreover, their critical role in the control of disease progression made them a prime target of research. Presently, limited information is available on HSPs in reference to their identification and structural classification across genera. To that extent, HSPIR provides manually curated information on sequence, structure, classification, ontology, domain organization, localization and possible biological functions extracted from UniProt, GenBank, Protein Data Bank and the literature. The database offers interactive search with incorporated tools, which enhances the analysis. HSPIR is a reliable resource for researchers exploring structure, function and evolution of HSPs. Availability:http://pdslab.biochem.iisc.ernet.in/hspir/ Contact:patrick@biochem.iisc.ernet.in Supplementary information: Supplementary data are available at Bioinformatics online.This publication has 20 references indexed in Scilit:
- The HSP70 chaperone machinery: J proteins as drivers of functional specificityNature Reviews Molecular Cell Biology, 2010
- InterPro: the integrative protein signature databaseNucleic Acids Research, 2008
- SMART 6: recent updates and new developmentsNucleic Acids Research, 2008
- Clustal W and Clustal X version 2.0Bioinformatics, 2007
- WoLF PSORT: protein localization predictorNucleic Acids Research, 2007
- Locating proteins in the cell using TargetP, SignalP and related toolsNature Protocols, 2007
- Molecular Chaperones and Protein Quality ControlCell, 2006
- The SWISS-PROT protein knowledgebase and its supplement TrEMBL in 2003Nucleic Acids Research, 2003
- The Protein Data BankNucleic Acids Research, 2000
- Gapped BLAST and PSI-BLAST: a new generation of protein database search programsNucleic Acids Research, 1997