K13-Propeller Polymorphisms in Plasmodium falciparum Parasites From Sub-Saharan Africa
Top Cited Papers
Open Access
- 2 November 2014
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 211 (8), 1352-1355
- https://doi.org/10.1093/infdis/jiu608
Abstract
Mutations in the Plasmodium falciparum K13-propeller domain have recently been shown to be important determinants of artemisinin resistance in Southeast Asia. This study investigated the prevalence of K13-propeller polymorphisms across sub-Saharan Africa. A total of 1212 P. falciparum samples collected from 12 countries were sequenced. None of the K13-propeller mutations previously reported in Southeast Asia were found, but 22 unique mutations were detected, of which 7 were nonsynonymous. Allele frequencies ranged between 1% and 3%. Three mutations were observed in >1 country, and the A578S was present in parasites from 5 countries. This study provides the baseline prevalence of K13-propeller mutations in sub-Saharan Africa.Keywords
This publication has 16 references indexed in Scilit:
- A molecular marker of artemisinin-resistant Plasmodium falciparum malariaNature, 2013
- Highly sensitive nanoscale spin-torque diodeNature Materials, 2013
- Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studiesThe Lancet Infectious Diseases, 2013
- Multiple populations of artemisinin-resistant Plasmodium falciparum in CambodiaNature Genetics, 2013
- Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast AsiaProceedings of the National Academy of Sciences of the United States of America, 2012
- No Evidence of Delayed Parasite Clearance after Oral Artesunate Treatment of Uncomplicated Falciparum Malaria in MaliThe American Journal of Tropical Medicine and Hygiene, 2012
- Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal studyThe Lancet, 2012
- A Major Genome Region Underlying Artemisinin Resistance in MalariaScience, 2012
- Artemisinin Resistance inPlasmodium falciparumMalariaNew England Journal of Medicine, 2009
- World Antimalarial Resistance Network (WARN) III: Molecular markers for drug resistant malariaMalaria Journal, 2007