Expansion and Activation Kinetics of Immune Cells during Early Phase of GVHD in Mouse Model Based on Chemotherapy Conditioning
Open Access
- 21 December 2010
- journal article
- research article
- Published by Hindawi Limited in Journal of Immunology Research
- Vol. 2010, 1-13
- https://doi.org/10.1155/2010/142943
Abstract
In the present paper, we have investigated early pathophysiological events in graft-versus-host disease (GVHD), a major complication to hematopoietic stem cell transplantation (HSCT). BLLB/c female mice conditioned with busulfan/cyclophosphamide (Bu-Cy) were transplanted with allogeneic male C57BL/6. Control group consisted of syngeneic transplanted Balb/c mice. In allogeneic settings, significant expansion and maturation of donor dendritic cells (DCs) were observed at dayFunding Information
- Swedish Cancer Foundation
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