Why Do We Expect Carotenoids to be Antioxidantsin vivo?
- 1 January 1997
- journal article
- research article
- Published by Informa UK Limited in Free Radical Research
- Vol. 26 (4), 381-398
- https://doi.org/10.3109/10715769709097818
Abstract
The antioxidant properties of β-carotene, in addition to its proposed immunomodulatory effects, have often been cited as the factors underlying its role in preventing disease initiation and propagation, yet the strongest evidence for diet and cancer prevention is based on fruit and vegetable intake and not β-carotene or other dietary carotenoids, per se. In the light of the outcome of the ATBC trial, the Physicians Health Study and the premature termination of the CARET study, this review addresses the issue of the antioxidant properties of the carotenoids and poses the questions: do dietary carotenes and xanthophylls have a clear role in disease prevention and are their antioxidant properties relevant to this role? What. do we know about their mechanisms of action in vitro as free radical scavengers?Keywords
This publication has 75 references indexed in Scilit:
- Effects of a Combination of Beta Carotene and Vitamin A on Lung Cancer and Cardiovascular DiseaseNew England Journal of Medicine, 1996
- Antioxidant activities of carotenes and xanthophyllsFEBS Letters, 1996
- Supplementation With Low Doses of Vitamin E Protects LDL From Lipid Peroxidation in Men and WomenArteriosclerosis, Thrombosis, and Vascular Biology, 1995
- Effect of in-vivo supplementation with low-dose vitamin E on susceptibility of low-density lipoprotein and high-density lipoprotein to oxidative modification.Journal of the American College of Nutrition, 1995
- Regulation and Regulatory Role of the RetinoidsCritical Reviews™ in Eukaryotic Gene Expression, 1995
- Carotenoid scavenging of radicalsZeitschrift für Lebensmittel-Untersuchung und Forschung, 1993
- The singlet oxygen and carotenoid interactionJournal of Photochemistry and Photobiology B: Biology, 1991
- Simultaneous electrochemical and electron paramagnetic resonance studies of carotenoid cation radicals and dicationsThe Journal of Physical Chemistry, 1991
- Orientation of β‐carotene and retinal in lipid bilayersFEBS Letters, 1981
- Free radicals and singlet oxygen scavengers: Reaction of a peroxy-radical with β-carotene, diphenyl furan and 1,4-diazobicyclo(2,2,2)-octaneBiochemical and Biophysical Research Communications, 1981