Protective Effect of Oral Administration of: A Traditional Medicine, Juzen-Taiho-To, and Its Components on LethalCandida AlbicansInfection in Immunosuppressed Mice
- 1 January 1998
- journal article
- research article
- Published by Informa UK Limited in Immunopharmacology and Immunotoxicology
- Vol. 20 (3), 421-431
- https://doi.org/10.3109/08923979809034824
Abstract
Protective effects of a kampo medicine, Juzen-taiho-to (TJ-48) and its herbal components against experimental candidiasis in cyclophosphamide-induced immunosuppressive mice were investigated. ICR mice were immunosuppressed by intraperitoneal treatment with cyclophosphamide (day-4) and were orally given TJ-48 or one of its 10 herbal components for 4 consecutive days (day-4-1). They were then challenged intravenously with a lethal dose of Candida albicans (day 0). An oral dose of 1g/kg/day of TJ-48 prolonged their life span. A similar protective effect was obtained by treatment with its component drugs Ginseng radix, Glycyrrhizae radix, Atractylodis lancea rhizoma or Cnidii rhizoma. These herbal components were suggested to have a main role in the protective effect of Juzen-taiho-to against Candida infection.Keywords
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