Cutaneous Recall Phenomenon at the Site of Previous Doxorubicin Extravasation After Second-Line Chemotherapy

Abstract

Recall inflammatory reactions of the skin have been described in the literature in connection with either prior radiation treatment or following extravasation of cytotoxic agents of the anthracycline family ( 1 – 3 ). Prolonged recall reactions may occur in skin at sites of irradiation, whereas inflammatory recall phenomena at sites of previous drug extravasation are rare and often occur as single events following administration of the same cytotoxic drug ( 1 , 2 ). Here we describe a case of inflammatory recall phenomenon at the site of previous drug extravasation.