A brief comparison of the pathophysiology of inflammatory versus neuropathic pain
- 1 August 2011
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Current Opinion in Anaesthesiology
- Vol. 24 (4), 400-407
- https://doi.org/10.1097/aco.0b013e32834871df
Abstract
Purpose of review The causes of inflammatory pain and neuropathic pain are fundamentally different. There are, however, common mechanisms underlying the generation of each pain state. We will discuss some specific elements observed in both tissue and nerve injury pain states and consider the hypothesis that these two states actually demonstrate a convergence over time. Recent findings The increased pain sensation following tissue and nerve injury results from several mechanisms, including altered ion channel expression in dorsal root ganglion neurons, enhanced dorsal horn glutamate release from primary afferents, enhanced glutamate receptor function in second-order neurons, disinhibition in the dorsal horn and glia cell activation. The role of specific subtypes of receptors, ion channels and glutamate transporters is revealed at peripheral and central sites. Importantly over time, a number of changes, in the dorsal root ganglion and in dorsal horn observed after tissue injury resemble changes observed after nerve injury. Summary Recognition of mechanisms common to both inflammatory pain and neuropathic pain might shed light on the understanding of the transition from acute pain to persistent pain.Keywords
This publication has 100 references indexed in Scilit:
- Skin Incision Induces Expression of Axonal Regeneration-Related Genes in Adult Rat Spinal Sensory NeuronsThe Journal of Pain, 2010
- VGLUT2-Dependent Sensory Neurons in the TRPV1 Population Regulate Pain and ItchNeuron, 2010
- VGLUT2-Dependent Glutamate Release from Nociceptors Is Required to Sense Pain and Suppress ItchNeuron, 2010
- Targeting Voltage-Gated Calcium Channels for Neuropathic Pain ManagementNeurotherapeutics, 2009
- Chloride regulation in the pain pathwayBrain Research Reviews, 2009
- MAP kinase and painBrain Research Reviews, 2009
- Dual regulation of Ca2+‐dependent glutamate release from astrocytes: Vesicular glutamate transporters and cytosolic glutamate levelsGlia, 2009
- Synaptic vesicle protein trafficking at the glutamate synapseNeuroscience, 2009
- Injury discharges regulate calcium channel alpha-2-delta-1 subunit upregulation in the dorsal horn that contributes to initiation of neuropathic painPain, 2008
- Descending serotonergic facilitation of spinal ERK activation and pain behaviorFEBS Letters, 2006