Shared Idiotypes Expressed by Human B-Cell Lymphomas
- 28 September 1989
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 321 (13), 851-857
- https://doi.org/10.1056/nejm198909283211302
Abstract
Each B-cell lymphoma expresses a surface immunoglobulin that contains unique antigenic determinants (idiotypes). We have produced 199 murine monoclonal antibodies reactive with the idiotypes isolated from 67 patients with follicular small-cleaved-cell lymphoma. These antiidiotype antibodies were analyzed for their ability to react with lymphoma cells from patients other than the one against which each antibody was made.Keywords
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