Threshold for Effects of Vitamin D Deficiency on Glucose Metabolism in Obese Female African-American Adolescents
Open Access
- 1 September 2009
- journal article
- other
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 94 (9), 3200-3206
- https://doi.org/10.1210/jc.2009-0445
Abstract
Context: Vitamin D status can influence insulin resistance. Objective: The aim of the study was to determine the prevalence of vitamin D deficiency in obese African-American (AA) adolescent females in a southeastern latitude and to determine the relationship of 25-hydroxyvitamin D [25(OH)D] with insulin and glucose dynamics. Design: We conducted a cross-sectional study in a University Children’s Hospital. Methods: Serum 25(OH)D, fasting glucose, PTH, serum calcium, serum lipids, serum transaminases, and C-reactive protein were assessed. Indices of insulin sensitivity and resistance were determined from an oral glucose tolerance test. Subjects were classified as vitamin D deficient or sufficient, based on the traditional vitamin D deficiency definition [serum 25(OH)D Results: A total of 51 AA adolescent females (body mass index, 43.3 ± 9.9 kg/m2; age, 14 ± 2 yr) were studied. Serum 25(OH)D concentrations were 20 ng/ml or less in 78.4% and 15 ng/ml or less in 60.8% of subjects. There were no significant group differences in the metabolic outcomes when subjects were classified using the traditional vitamin D deficiency definition. The Matsuda index of insulin sensitivity was significantly lower (P = 0.02), and insulin area under the curve was significantly higher (P = 0.04) in subjects with 25(OH)D concentrations of 15 ng/ml or less vs. those with higher concentrations. Conclusions: Vitamin D deficiency is highly prevalent in obese, AA female adolescents and may promote insulin resistance. Our data suggest that a 25(OH)D concentration of 15 ng/ml or less may be the threshold by which vitamin D deficiency confers negative effects on insulin sensitivity. The results suggest that 25(OH)D concentrations ≤15 ng/mL may be the threshold by which vitamin D deficiency confers negative effects on insulin sensitivity.Keywords
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