Modeling and analyzing HIV transmission: the effect of contact patterns
- 1 December 1988
- journal article
- Published by Elsevier BV in Mathematical Biosciences
- Vol. 92 (2), 119-199
- https://doi.org/10.1016/0025-5564(88)90031-4
Abstract
A compartmental model is presented for the spread of HIV in a homosexual population divided into subgroups by degree of sexual activity. The model includes constant recruitment rates for the susceptibles in the subgroups. It incorporates the long infectious period of HIV-infected individuals and allows one to vary infectiousness over the infectious period. A new pattern of mixing, termed preferred mixing, is defined, in which a fraction of a group's contacts can be reserved for within-group contacts, the remainder being subject to proportional mixing. The fraction reserved may differ among groups. In addition, the classic definition of reproductive number is generalized to show that for heterogeneous populations in general the endemic threshold is [beta]DcY, where cY is the mean number of contacts per infective. The most important finding is that the pattern of contacts between the different groups has a major effect on the spread of HIV, an effect inadequately recognized or studied heretoforeKeywords
This publication has 68 references indexed in Scilit:
- The spread and persistence of infectious diseases in structured populationsMathematical Biosciences, 1988
- Epidemiological models for heterogeneous populations: proportionate mixing, parameter estimation, and immunization programsMathematical Biosciences, 1987
- Eradication of infectious diseases in heterogeneous populationsMathematical Biosciences, 1987
- Modeling the incidence of Acquired Immunodeficiency Syndrome (AIDS) in San Francisco, Los Angeles, and New YorkMathematical Modelling, 1986
- Persistent HIV antigenaemia and decline of HIV core antibodies associated with transition to AIDS.BMJ, 1986
- The AIDS EpidemicNew England Journal of Medicine, 1985
- Age-related changes in the rate of disease transmission: implications for the design of vaccination programmesEpidemiology and Infection, 1985
- Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)Science, 1983
- Immunodeficiency in Female Sexual Partners of Men with the Acquired Immunodeficiency SyndromeNew England Journal of Medicine, 1983
- Epidemics and Rumours: A SurveyJournal of the Royal Statistical Society. Series A (General), 1967