The unique sources of stress for professional women are discrimination, stereotyping, the marriage/work interface, and social isolation. The behavioral, physiological, and psychological consequences of mismanaged stress are examined and four preventive stress management moderators specifically for professional women suggested. These moderators that influence the stress-strain relationships are a mentor, locus of control, self-confidence, and self-awareness. Finally, a three-point research agenda is outlined for extending understanding of stress among professional women.