Chemistry of mycolactones, the causative toxins of Buruli ulcer
- 7 March 2011
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 108 (17), 6703-6708
- https://doi.org/10.1073/pnas.1015252108
Abstract
Buruli ulcer is a severe and devastating skin disease caused by Mycobacterium ulcerans infection, yet it is one of the most neglected diseases. The causative toxin, referred to as mycolactone A/B, was isolated and characterized as a polyketide-derived macrolide in 1999. The current status of the mycolactone chemistry is described, highlighting the stereochemistry assignment of mycolactone A/B; total synthesis; the structure determination of mycolactone congeners from the human pathogen M. ulcerans, the frog pathogen Mycobacterium liflandii, and the fish pathogen Mycobacterium marinum; the structural diversity in the mycolactone class of natural products; the highly sensitive detection/structure-analysis of mycolactones; and some biological activity.Keywords
This publication has 41 references indexed in Scilit:
- Synthesis and structure assignment of the minor metabolite arising from the frog pathogen Mycobacterium liflandiiTetrahedron Letters, 2010
- Scalable and efficient synthesis of the mycolactone coreTetrahedron, 2010
- Fine-Needle Aspiration, an Efficient Sampling Technique for Bacteriological Diagnosis of Nonulcerative Buruli UlcerJournal of Clinical Microbiology, 2009
- Synthesis and Structure of Mycolactone E Isolated from Frog MycobacteriumOrganic Letters, 2008
- Mycolactone Is Responsible for the Painlessness of Mycobacterium ulcerans Infection (Buruli Ulcer) in a Murine StudyInfection and Immunity, 2008
- Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteriaNatural Product Reports, 2008
- A Novel Mycolactone Toxin Obtained by Biosynthetic EngineeringChemBioChem, 2007
- Total synthesis of mycolactones A and BTetrahedron, 2007
- Evolution of Mycobacterium ulcerans and Other Mycolactone-Producing Mycobacteria from a Common Mycobacterium marinum ProgenitorJournal of Bacteriology, 2007
- Globally Distributed Mycobacterial Fish Pathogens Produce a Novel Plasmid-Encoded Toxic Macrolide, Mycolactone FInfection and Immunity, 2006