Interleukin-10 and Immunity against Prokaryotic and Eukaryotic Intracellular Pathogens
- 1 August 2011
- journal article
- review article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 79 (8), 2964-2973
- https://doi.org/10.1128/iai.00047-11
Abstract
The generation of an effective immune response against an infection while also limiting tissue damage requires a delicate balance between pro- and anti-inflammatory responses. Interleukin-10 (IL-10) has potent immunosuppressive effects and is essential for regulation of immune responses. However, the immunosuppressive properties of IL-10 can also be exploited by pathogens to facilitate their own survival. In this minireview, we discuss the role of IL-10 in modulating intracellular bacterial, fungal, and parasitic infections. Using information from several different infection models, we bring together and highlight some common pathways for IL-10 regulation and function that cannot be fully appreciated by studies of a single pathogen.Keywords
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