The role of homologous recombination repair in the formation of chromosome aberrations
- 1 May 2004
- journal article
- review article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 104 (1-4), 21-27
- https://doi.org/10.1159/000077462
Abstract
The repair of DNA double strand breaks by homologous recombination can occur by at least two pathways: a Rad51-dependent pathway that is predominantly error free, and a Rad51-independent pathway (single strand annealing, SSA) that is error prone. In theory, chromosome exchanges can result from (mis)repair by either pathway. Both repair pathways will involve a search for homologous sequence, leading to co-localization of chromatin. Genes involved in homologous recombination repair (HRR) have now been successfully knocked out in mice and the role of HRR in the formation of chromosome exchanges, particularly after ionising radiation, is discussed in the light of new evidence.Keywords
This publication has 33 references indexed in Scilit:
- Drosophila Checkpoint Kinase 2 Couples Centrosome Function and Spindle Assembly to Genomic IntegrityCell, 2003
- Chromosome positioning in the interphase nucleusTrends in Cell Biology, 2002
- Jumping translocations are common in solid tumor cell lines and result in recurrent fusions of whole chromosome armsGenes, Chromosomes and Cancer, 2001
- The Relationship between Homology Length and Crossing Over during the Repair of a Broken ChromosomePublished by Elsevier BV ,2000
- Underprediction of visibly complex chromosome aberrations by a recombinational-repair ('one-hit') modelInternational Journal of Radiation Biology, 2000
- Genetic and Physical Analyses of the Centromeric and Pericentromeric Regions of Human Chromosome 5: Recombination across 5cenGenomics, 1999
- Effectiveness of 0.28 keV carbon K ultrasoft X-rays at producing simple and complex chromosome exchanges in human fibroblasts in vitro detected using FISHInternational Journal of Radiation Biology, 1998
- Rearrangement of human cell homologous chromosome domains in response to ionizing radiationInternational Journal of Radiation Biology, 1997
- Dose-response curves for simple and complex chromosome aberrations induced by X-rays and detected using fluorescence in situ hybridizationInternational Journal of Radiation Biology, 1996
- Transvection, nuclear structure, and chromatin proteins.The Journal of cell biology, 1993