High-Risk Human Papillomaviral Oncogenes E6 and E7 Target Key Cellular Pathways to Achieve Oncogenesis
Top Cited Papers
Open Access
- 7 June 2018
- journal article
- review article
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 19 (6), 1706
- https://doi.org/10.3390/ijms19061706
Abstract
Infection with high-risk human papillomavirus (HPV) has been linked to several human cancers, the most prominent of which is cervical cancer. The integration of the viral genome into the host genome is one of the manners in which the viral oncogenes E6 and E7 achieve persistent expression. The most well-studied cellular targets of the viral oncogenes E6 and E7 are p53 and pRb, respectively. However, recent research has demonstrated the ability of these two viral factors to target many more cellular factors, including proteins which regulate epigenetic marks and splicing changes in the cell. These have the ability to exert a global change, which eventually culminates to uncontrolled proliferation and carcinogenesis.Keywords
This publication has 198 references indexed in Scilit:
- A Review of Clinical Trials of Human Papillomavirus Prophylactic VaccinesVaccine, 2012
- The HPV E6 oncoprotein targets histone methyltransferases for modulating specific gene transcriptionOncogene, 2011
- Quadrivalent human papillomavirus vaccination and trends in genital warts in Australia: analysis of national sentinel surveillance dataThe Lancet Infectious Diseases, 2011
- Destabilization of TIP60 by Human Papillomavirus E6 Results in Attenuation of TIP60-Dependent Transcriptional Regulation and Apoptotic PathwayMolecular Cell, 2010
- Epigenetic Silencing of Interferon-κ in Human Papillomavirus Type 16–Positive CellsCancer Research, 2009
- Human papilloma virus is associated with breast cancerBritish Journal of Cancer, 2009
- Human papillomavirus type 16 E2 and E6 are RNA-binding proteins and inhibit in vitro splicing of pre-mRNAs with suboptimal splice sitesVirology, 2009
- Viral oncoproteins target the DNA methyltransferasesOncogene, 2006
- Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif proteinNature, 2002
- UBE3A/E6-AP mutations cause Angelman syndromeNature Genetics, 1997