Effects of prenatal micronutrient supplementation on complications of labor and delivery and puerperal morbidity in rural Nepal
- 15 April 2009
- journal article
- research article
- Published by Wiley in International Journal of Gynecology & Obstetrics
- Vol. 106 (1), 3-7
- https://doi.org/10.1016/j.ijgo.2009.03.040
Abstract
To examine the effect of supplemental prenatal folic acid, folic acid-iron, folic acid-iron-zinc, and multiple micronutrients on maternal morbidity in rural Nepal. A cluster-randomized double-masked controlled trial of pregnant women who received daily supplements from early pregnancy through 3 months post partum as per the treatment allocation. Women were interviewed at birth about labor and delivery complications and for 9 days post partum to obtain 24-hour histories of morbidity. A total of 3986 (97.3%) women completed an interview regarding labor and delivery; morbidity history was available for 3564 (87.0%) women. Folic acid-iron reduced the risk of postpartum hemorrhage (relative risk [RR] 0.59; 95% confidence interval [CI] 0.35-0.98). Risk of dysfunctional labor increased with multiple micronutrient supplementation (RR 1.28; 95% CI, 1.01-1.60), although preterm premature rupture of membrane decreased (RR 0.40; 95% CI, 0.21-0.79). Puerperal sepsis was lower in those receiving folic acid-iron, folic acid-iron-zinc, and multiple micronutrients compared with controls (P<0.05). Prenatal folic acid-iron supplementation reduced the risk of obstetric complications in this South Asian setting.This publication has 21 references indexed in Scilit:
- Nutrition and Maternal Survival in Developing CountriesPublished by Springer Science and Business Media LLC ,2008
- Meeting MDG-5: an impossible dream?The Lancet, 2006
- World Health Organization randomized trial of calcium supplementation among low calcium intake pregnant womenAmerican Journal of Obstetrics and Gynecology, 2006
- Incidence of severe pre‐eclampsia, postpartum haemorrhage and sepsis as a surrogate marker for severe maternal morbidity in a European population‐based study: the MOMS‐B surveyBJOG: An International Journal of Obstetrics and Gynaecology, 2004
- Effects of alternative maternal micronutrient supplements on low birth weight in rural Nepal: double blind randomised community trialBMJ, 2003
- Double blind, cluster randomised trial of low dose supplementation with vitamin A or beta carotene on mortality related to pregnancy in NepalBMJ, 1999
- A validation study of maternal self reports of obstetrical complications: implications for health surveysInternational Journal of Gynecology & Obstetrics, 1998
- Effect of increasing root‐zone temperature on growth and nutrient uptake by ‘gold star’ muskmelon plants1Journal of Plant Nutrition, 1998
- Longitudinal data analysis using generalized linear modelsBiometrika, 1986
- DIET AS A PROPHYLACTIC AGENT AGAINST PUERPERAL SEPSISBMJ, 1931