Epilepsy and Dementia in the Elderly
Open Access
- 3 March 2008
- journal article
- review article
- Published by S. Karger AG in Dementia and Geriatric Cognitive Disorders
- Vol. 25 (4), 293-300
- https://doi.org/10.1159/000119103
Abstract
Epilepsy is a frequent condition in the elderly; however, it remains a relatively understudied condition in older adults with dementia. The diagnosis of a seizure is particularly difficult and is most often based on questions to the caregiver. Epilepsy in dementia has significant consequences on the prognosis of the underlying dementia: it can result in a worsening of cognitive performance, particularly in language, as well as a reduction in autonomy, a greater risk of injury and a higher mortality rate. In this review, management strategies are recommended for the clinician. The presence of pre-existing Alzheimer's disease does not exempt the clinician from ruling out other symptomatic causes of seizures. Anti-epileptic drugs (AED) should be started only after the diagnosis has been clearly established, when the risk of recurrence is high, and with monotherapy whenever possible. Although few data are available, the more recent AED offer significant advantages over the older medications in this context.Keywords
This publication has 89 references indexed in Scilit:
- Effectiveness of Atypical Antipsychotic Drugs in Patients with Alzheimer's DiseaseNew England Journal of Medicine, 2006
- Dementia in Subjects Aged 75 Years or Over within the PAQUID Cohort: Prevalence and Burden by SeverityDementia and Geriatric Cognitive Disorders, 2006
- Epilepsy in elderly peopleBMJ, 2005
- Occurrence of Cognitive Impairment and Dementia after the Age of 60: A Population-Based Study from Northern ItalyDementia and Geriatric Cognitive Disorders, 2005
- Drug Treatment of Epilepsy in Elderly PeopleDrugs & Aging, 2003
- Newly Diagnosed Unprovoked Epileptic Seizures: Presentation at Diagnosis in CAROLE StudyEpilepsia, 2001
- Treating Epilepsy in the ElderlyDrug Safety, 2001
- Epilepsy in elderly peopleThe Lancet, 2000
- Seizures in Acute Stroke: Predictors and Prognostic SignificanceStroke, 1997
- Epileptic Seizures in Elderly Patients with DementiaEpilepsia, 1992