Advances and Challenges in Basic and Translational Research on Clusterin

Abstract
The 5th International Clusterin Workshop, held in Spetses, Greece on June 2–5, 2008, brought together researchers active in this field to focus on clarifying the mechanisms of this unique protein for executing the fate of a cell. Based on new findings presented, a full debate on whether CLU has a key role in tumor prevention or tumor promotion led to some consensus that it may depend on the context of its expression and the microenvironment.