Strategies for Targeting Protein–Protein Interactions With Synthetic Agents

Abstract

The development of small‐molecule modulators of protein–protein interactions is a formidable goal, albeit one that possesses significant potential for the discovery of novel therapeutics. Despite the daunting challenges, a variety of examples exists for the inhibition of two large protein partners with low‐molecular‐weight ligands. This review discusses the strategies for targeting protein–protein interactions and the state of the art in the rational design of molecules that mimic the structures and functions of their natural targets.