Brain edema during ischemia and after restoration of blood flow. Measurement of water, sodium, potassium content and plasma protein permeability.
- 1 September 1979
- journal article
- abstracts
- Published by Ovid Technologies (Wolters Kluwer Health) in Stroke
- Vol. 10 (5), 542-547
- https://doi.org/10.1161/01.str.10.5.542
Abstract
The left cerebral hemisphere of Mongolian gerbils was used to elucidate the mechanisms of brain edema which develop during cerebral ischemia and after restoration of cerebral blood flow following temporary ischemia. Water content was measured by the tissue-drying method. Sodium and potssium ion concentration was measured by flame photometry. Passage of 131I-albumin (RISA) from blood to the cerebral parenchyma was measured on a gamma scintillation counter. Our findings indicate that pure cytotoxic edema develops during ischemia and during a short period after restoration of cerebral blood flow. Vasogenic edema, which is accelerated by the leakage of plasma constitutents from blood due to blood-brain barrier damage, developed after restoration of the cerebral blood flow. After less than 1 hr of ischemia, restoration of the cerebral blood flow drastically reduced the degree of brain edema. However, restoration of the cerebral blood flow greatly worsened the brain edema following more than 3 hr of ischemia.This publication has 27 references indexed in Scilit:
- Experimental regional cerebral ischemia in the middle cerebral artery territory in primates. Part 3: effects on brain water and electrolytes in the late phase of acute MCA stroke.Stroke, 1978
- The Role of Monoamines and Cyclic AMP in Ischemic Brain EdemaPublished by Springer Science and Business Media LLC ,1976
- Cerebral Changes during Recirculation Following Temporary Ischemia in Mongolian GerbilsNeurologia medico-chirurgica, 1976
- Ischaemic swelling of cerebral hemisphere in the gerbil.Journal of Neurology, Neurosurgery & Psychiatry, 1975
- Resuscitation of the monkey brain after one hour's complete ischemia. II. Brain water and electrolytesBrain Research, 1975
- Effect of experimental ischemia on cerebral water and electrolytesJournal of Neurosurgery, 1974
- Transport of proteins across normal cerebral arteriolesJournal of Comparative Neurology, 1973
- Hemodynamic and metabolic concomitants of brain swelling and cerebral edema due to experimental cerebral infarctionJournal of Neurosurgery, 1972
- Effects of experimental ischemia on electrolytes of cortical cerebrospinal fluid and on brain waterJournal of Neurosurgery, 1972
- Experimental Cerebral Infarction: Modification by Treatment with Hemodiluting, Hemoconcentrating, and Dehydrating AgentsJournal of Neurosurgery, 1967