The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission
Open Access
- 10 March 2014
- journal article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 204 (6), 919-929
- https://doi.org/10.1083/jcb.201308006
Abstract
OPA1 processing by YEM1L and OMA1 is dispensable for mitochondrial fusion and instead drives mitochondrial fragmentation, which is crucial for mitochondrial integrity and quality control.Keywords
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