Prognostic values of immune scores and immune microenvironment-related genes for hepatocellular carcinoma
Open Access
- 25 March 2020
- journal article
- research article
- Published by Impact Journals, LLC in Aging
- Vol. 12 (6), 5479-5499
- https://doi.org/10.18632/aging.102971
Abstract
It is crucial to grasp the characteristics of tumour immune microenvironment to improve effects of immunotherapy. In this study, the immune and stromal scores of 371 cases were calculated for quantitative analysis of immune and stromal cell infiltration in the tumour microenvironment of hepatocellular carcinoma (HCC). The weighted gene co-expression network analysis and protein-protein interaction network were analysed to identify immune microenvironment-related genes. The results showed that patients with high immune scores had a higher 4-year recurrence-free rate. TP53, CTNNB1, and AXIN1 mutations significantly varied with immune scores. In immune score-related modules analysis, Kyoto encyclopaedia of genes and genomes pathways and gene ontology terms were closely related to immune processes, tumorigenesis, and metastasis. Twelve new immune microenvironment-related genes were identified and had significantly positive correlations with seven immune checkpoint genes. In prognostic analysis, eleven immune microenvironment-related genes exhibited high expression, nine of which were validated in the GSE62232 dataset and were significantly associated with a good prognosis. Our findings suggest that calculating immune score and stromal score could help to determine tumour purity and immune cell infiltration in the tumour microenvironment. Nine immune microenvironment-related genes identified in this study had potential as prognostic markers for HCC.Keywords
This publication has 29 references indexed in Scilit:
- Integrated genomic profiling expands clinical options for patients with cancerNature Biotechnology, 2019
- Immunotherapy for the First-Line Treatment of Patients with Metastatic Non–Small Cell Lung CancerClinical Cancer Research, 2019
- Immune Gene Expression Is Associated with Genomic Aberrations in Breast CancerCancer Research, 2017
- Coinhibitory Pathways in Immunotherapy for CancerAnnual Review of Immunology, 2016
- Nivolumab and Ipilimumab versus Ipilimumab in Untreated MelanomaThe New England Journal of Medicine, 2015
- Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012International Journal of Cancer, 2014
- Inferring tumour purity and stromal and immune cell admixture from expression dataNature Communications, 2013
- Advances and perspectives in immunotherapy of melanomaAnnals of Oncology, 2012
- Accessories to the Crime: Functions of Cells Recruited to the Tumor MicroenvironmentCancer Cell, 2012
- The Continuing Increase in the Incidence of Hepatocellular Carcinoma in the United States: An UpdateAnnals of Internal Medicine, 2003