The Continuous Glucose Monitoring System (CGMS) in type 1 diabetic children is the way to reduce hypoglycemic risk
- 22 July 2002
- journal article
- research article
- Published by Wiley in Diabetes/Metabolism Research and Reviews
- Vol. 18 (4), 324-329
- https://doi.org/10.1002/dmrr.309
Abstract
Background Diabetic children treated with intensive insulin therapy are showing a dangerous increase in severe hypoglycemic episodes. The Continuous Glucose Monitoring System (CGMS) allows glycemic profiles to be monitored over a 72‐h period. The aim of the present study was to evaluate whether this system is sufficiently sensitive to detect asymptomatic hypoglycemia, and to determine if its periodic application would help to minimize the hypoglycemic risk in children with type 1 diabetes mellitus (T1DM). Methods Twenty‐seven T1DM children (age range 6–13.1 years) were enrolled in the study. The sensor was inserted subcutaneously in each patient and the standard four or five registrations of capillary glycemia per day were performed. Eighteen patients continued in the study and the glucose sensor was again inserted after a 6‐week interval. At the beginning and end of the study, fructosamine, glycosylated hemoglobin (HbA1c), median glycemia, number and duration of hypoglycemic events and insulin requirement were evaluated. Results A significantly higher number of asymptomatic hypoglycemic events was revealed by CGMS in comparison with the standard system (3.6 ± 2.3 vs 0.7 ± 0.9; p < 0.0001). In patients who continued in the study, insulin therapy adjustments reduced the incidence of hypoglycemic events (2.5 ± 1.7 vs 3.9 ± 2.2; p < 0.05). At the 6‐week point, the fructosamine level was reduced (330 ± 30 vs 349 ± 24 µmol/l; p < 0.05). Conclusions The CGMS is a useful device not only for detecting unrecognized hypoglycemia, but also for modifying insulin therapy in order to reduce hypoglycemic events. The system appears to be useful in avoiding long exposure to hypoglycemia. Copyright © 2002 John Wiley & Sons, Ltd.This publication has 19 references indexed in Scilit:
- Sensors for glucose monitoring: technical and clinical aspectsDiabetes/Metabolism Research and Reviews, 2001
- Continuous Subcutaneous Glucose Monitoring in Children With Type 1 DiabetesPublished by American Academy of Pediatrics (AAP) ,2001
- Alterations in sleep physiology in young children with insulin-dependent diabetes mellitus: Relationship to nocturnal hypoglycemiaThe Journal of Pediatrics, 2000
- Hypoglycaemia and the neonatal brain.European Journal of Pediatrics, 1999
- Adverse events in intensively treated children and adolescents with type 1 diabetesActa Paediatrica, 1999
- Conventional versus intensive diabetes therapy in children with type 1 diabetes: effects on memory and motor speed.Diabetes Care, 1999
- Cognitive function and mood after profound nocturnal hypoglycaemia in prepubertal children with conventional insulin treatment for diabetesArchives of Disease in Childhood, 1999
- Counterregulation during spontaneous nocturnal hypoglycemia in prepubertal children with type 1 diabetes.Diabetes Care, 1999
- The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes MellitusNew England Journal of Medicine, 1993
- Severe Hypoglycemia in IDDM ChildrenDiabetes Care, 1989