Evaluation of Powdered Cellulose as a Direct Compression Carrier

Abstract

The feasibility of the use of Solka Floc® as a direct com preosion carrier was investiated. The powder characteristics of the six Brades of Solka Floc were evaluated and compared to Avice®. Various parameters studied, include, particle size, bulk density, moisture content, and flow characteristics. The compressional characteristics were investigated for Solka Floc. The particulate grade of Solka Floc in combination with Avicel had an adequate compressional charaeteristicr. Tablets were made with acetaminophen from coabination of Solku Floc and Avicel and from Avicel alone. The tablets from both forulotions were corprrable with respect to weight variation, hardness variation, thickness variation, friability, and disintegration time.