Rapid and Efficient Synthesis of 4‐Substituted Pyrazol‐5‐one under Microwave Irradiation in Solvent‐Free Conditions
- 12 November 2007
- journal article
- research article
- Published by Wiley in Archiv der Pharmazie
- Vol. 340 (11), 591-598
- https://doi.org/10.1002/ardp.200700121
Abstract
New heterocyclic compounds containing pyrazol-5-one coupled with benzimidazole, benzothiazole, benzoxazole, quinoline, naphthyridin, and pyrazole were synthesized. Comparative investigations to synthesize these interesting classes of heterocyclic compounds through conventional heating or under microwave-irradiation conditions were presented. Synthesized compounds 1a, 2a, 4k, 3a, c, 5a, b, 6b, 7a, b, d, 8a, and 9a were evaluated for their antitumor activity. Some of these compounds exhibited promising antitumor activity.Keywords
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