Adriamycin, 14-Hydroxydaunomycin, a new antitumor antibiotic fromS. peucetius var.caesius
- 20 March 2000
- journal article
- other
- Published by Wiley in Biotechnology & Bioengineering
- Vol. 67 (6), 704-713
- https://doi.org/10.1002/(sici)1097-0290(20000320)67:6<704::aid-bit8>3.0.co;2-l
Abstract
Streptomyces peucetius var. caesius, obtained from S. peucetius, the daunomycin producing microorganism, by mutagenic treatment, differs from the parent culture by the color of the vegetative and aerial mycelia and by its antibiotic producing ability. S. peucetius var. caesius accumulates adriamycin in submerged and aerated culture on a medium containing glucose, brewer's yeast, and inorganic salts both in shake flasks and in stirred fermenters. Isolation of the product is performed by solvent extraction, chromatography on buffered cellulose columns, and crystallization as the hydrochloride. The new antitumor agent, adriamycin, is the 14‐hydroxy derivative of daunomycin.Keywords
This publication has 7 references indexed in Scilit:
- Adriamycin (14-hydroxydaunomycin), a novel antitumor antibioticTetrahedron Letters, 1969
- The total absolute configuration of daunomycinTetrahedron Letters, 1968
- The structure of daunomycinTetrahedron Letters, 1968
- Daunomycin. II. The Structure and Stereochemistry of DaunosamineJournal of the American Chemical Society, 1964
- Daunomycin. I. The Structure of DaunomycinoneJournal of the American Chemical Society, 1964
- A Guide for the Classification of Streptomycetes According to Selected Groups. Placement of Strains in Morphological SectionsApplied and Environmental Microbiology, 1958
- DETERMINATION OF BLOOD SUGARPublished by Elsevier BV ,1945