Biological Activities of Polyphenols from Grapes
Open Access
- 4 February 2010
- journal article
- review article
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 11 (2), 622-646
- https://doi.org/10.3390/ijms11020622
Abstract
The dietary consumption of grape and its products is associated with a lower incidence of degenerative diseases such as cardiovascular disease and certain types of cancers. Most recent interest has focused on the bioactive phenolic compounds in grape. Anthocyanins, flavanols, flavonols and resveratrol are the most important grape polyphenols because they possess many biological activities, such as antioxidant, cardioprotective, anticancer, anti-inflammation, antiaging and antimicrobial properties. This review summarizes current knowledge on the bioactivities of grape phenolics. The extraction, isolation and identification methods of polyphenols from grape as well as their bioavailability and potential toxicity also are included.Keywords
This publication has 131 references indexed in Scilit:
- Grape Waste Extract Obtained by Supercritical Fluid Extraction Contains Bioactive Antioxidant Molecules and Induces Antiproliferative Effects in Human Colon Adenocarcinoma CellsJournal of Medicinal Food, 2009
- Grape-seed procyanidins prevent low-grade inflammation by modulating cytokine expression in rats fed a high-fat dietThe Journal of Nutritional Biochemistry, 2009
- Antibacterial Effects of Grape Extracts onHelicobacter pyloriApplied and Environmental Microbiology, 2009
- Phenolic compounds and antioxidant activities of skins and seeds of five wild grapes and two hybrids native to JapanJournal of Food Composition and Analysis, 2008
- Influence of phenolic compounds from wines on the growth of Listeria monocytogenesFood Control, 2007
- Rejuvenation of antioxidant system in central nervous system of aged rats by grape seed extractNeuroscience Letters, 2005
- The Chemistry behind Antioxidant Capacity AssaysJournal of Agricultural and Food Chemistry, 2005
- Comparative Effects of Food-Derived Polyphenols on the Viability and Apoptosis of a Human Hepatoma Cell Line (HepG2)Journal of Agricultural and Food Chemistry, 2005
- Anthocyanins induce cell cycle perturbations and apoptosis in different human cell linesCarcinogenesis: Integrative Cancer Research, 2004
- Decomposition of Cocoa Procyanidins in the Gastric MilieuBiochemical and Biophysical Research Communications, 2000