Validation of the Diabetes Prevention Trial–Type 1 Risk Score in the TrialNet Natural History Study
Open Access
- 16 June 2011
- journal article
- Published by American Diabetes Association in Diabetes Care
- Vol. 34 (8), 1785-1787
- https://doi.org/10.2337/dc11-0641
Abstract
OBJECTIVE We assessed the accuracy of the Diabetes Prevention Trial–Type 1 Risk Score (DPTRS), developed from the Diabetes Prevention Trial–Type 1 (DPT-1), in the TrialNet Natural History Study (TNNHS). RESEARCH DESIGN AND METHODS Prediction accuracy of the DPTRS was assessed with receiver-operating characteristic curve areas. The type 1 diabetes cumulative incidence within the DPTRS intervals was compared between the TNNHS and DPT-1 cohorts. RESULTS Receiver-operating characteristic curve areas for the DPTRS were substantial in the TNNHS (P < 0.001 at both 2 and 3 years). The type 1 diabetes cumulative incidence did not differ significantly between the TNNHS and DPT-1 cohorts within DPTRS intervals. In the TNNHS, 2-year and 3-year risks were low for DPTRS intervals <6.50 (<0.10 and <0.20, respectively). Thresholds ≥7.50 were indicative of high risk in both cohorts (2-year risks: 0.49 in the TNNHS and 0.51 in DPT-1). CONCLUSIONS The DPTRS is an accurate and robust predictor of type 1 diabetes in autoantibody-positive populations.This publication has 11 references indexed in Scilit:
- The TrialNet Natural History Study of the Development of Type 1 Diabetes: objectives, design, and initial resultsPediatric Diabetes, 2009
- A Risk Score for Type 1 Diabetes Derived From Autoantibody-Positive Participants in the Diabetes Prevention Trial–Type 1Diabetes Care, 2008
- Should We Screen for Risk of Type 1 Diabetes?Diabetes Care, 2008
- T-Cell Responses to Islet Antigens Improves Detection of Autoimmune Diabetes and Identifies Patients With More Severe β-Cell Lesions in Phenotypic Type 2 DiabetesDiabetes, 2007
- Increasing the Accuracy of Oral Glucose Tolerance Testing and Extending Its Application to Individuals With Normal Glucose Tolerance for the Prediction of Type 1 DiabetesDiabetes Care, 2007
- Models for Predicting Type 1 Diabetes in Siblings of Affected ChildrenDiabetes Care, 2006
- Effects of Oral Insulin in Relatives of Patients With Type 1 DiabetesDiabetes Care, 2005
- Testing the Accelerator HypothesisDiabetes Care, 2003
- Effects of Insulin in Relatives of Patients with Type 1 Diabetes MellitusThe New England Journal of Medicine, 2002
- Time‐Dependent ROC Curves for Censored Survival Data and a Diagnostic MarkerBiometrics, 2000