YCA1 participates in the acetic acid induced yeast programmed cell death also in a manner unrelated to its caspase‐like activity
- 29 November 2006
- journal article
- Published by Wiley in FEBS Letters
- Vol. 580 (30), 6880-6884
- https://doi.org/10.1016/j.febslet.2006.11.050
Abstract
Yeast cells lacking the metacaspase-encoding gene YCA1 (Deltayca1) were compared with wild-type (WT) cells with respect to the occurrence, nature and time course of acetic-acid triggered death. We show that Deltayca1 cells undergo programmed cell death (PCD) with a rate lower than that of the WT and that PCD in WT cells is caused at least in part by the caspase activity of Yca1p. Since in Deltayca1 cells this effect is lost, but z-VAD-fmk does not prevent both WT and Deltayca1 cell death, PCD in WT cells occurs via a Yca1p caspase and a non-caspase route with similar characteristics.Keywords
This publication has 29 references indexed in Scilit:
- Specific modulation of apoptosis and Bcl-xL phosphorylation in yeast by distinct mammalian protein kinase C isoformsJournal of Cell Science, 2006
- Viruses activate a genetically conserved cell death pathway in a unicellular organismThe Journal of cell biology, 2005
- H2B (Ser10) Phosphorylation is Induced during Apoptosis and Meiosis in S. cerevisiaeCell Cycle, 2005
- Natural conditions inducing programmed cell death in the yeast Saccharomyces cerevisiaeBiochemistry (Moscow), 2005
- Valproic acid induces apoptosis dependent of Yca1p at concentrations that mildly affect the proliferation of yeastFEBS Letters, 2005
- Mitochondrial fission proteins regulate programmed cell death in yeastGenes & Development, 2004
- Chronological aging leads to apoptosis in yeastThe Journal of cell biology, 2004
- TheS. cerevisiaeHtrA-like protein Nma111p is a nuclear serine protease that mediates yeast apoptosisJournal of Cell Science, 2004
- Programmed death in yeast as adaptation?FEBS Letters, 2002
- Identification of Paracaspases and MetacaspasesMolecular Cell, 2000